Clinical pharmacokinetic monitoring and resistance testing for the optimisation of antiviral therapy targeting human cytomegalovirus
D Wong - 2022 - unsworks.unsw.edu.au
… novel ganciclovir-resistant mutations examined in this study ....… analysis of a patient specimen
with sufficient viral load. The … with valganciclovir for CMV retinitis in AIDS patients [191]. The …
with sufficient viral load. The … with valganciclovir for CMV retinitis in AIDS patients [191]. The …
[HTML][HTML] Pathogenesis of human cytomegalovirus in the immunocompromised host
P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
… about serial measures of the viral load to explain features of … an enlarged T cell compartment
dominated by anti-HCMV T … commonly used to treat ganciclovir-resistant strains of HCMV, …
dominated by anti-HCMV T … commonly used to treat ganciclovir-resistant strains of HCMV, …
Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance
S Chou - Antiviral research, 2020 - Elsevier
… in components of the terminase complex responsible for cleavage of freshly replicated …
readout of mutations shown to knock out viral viability in 9 specimens with a median viral load of …
readout of mutations shown to knock out viral viability in 9 specimens with a median viral load of …
Advances in the development of therapeutics for cytomegalovirus infections
E Acosta, T Bowlin, J Brooks, L Chiang… - The Journal of …, 2020 - academic.oup.com
… CMV [60], and retained activity against ganciclovir-resistant isolates of CMV having mutations
… , foretelling significant patient benefits of improved control of viral load, minimized adverse …
… , foretelling significant patient benefits of improved control of viral load, minimized adverse …
[HTML][HTML] Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighting the Role of Advanced Practice Providers …
WV Cochran, MV Dioverti, J Langlee… - Annals of …, 2024 - ncbi.nlm.nih.gov
… , longitudinal study in the USA, where multiple-course anti-… of CMV viral load is often used
to diagnose CMV infection, … recipients with ganciclovir-resistant or refractory CMV infection, 5 (…
to diagnose CMV infection, … recipients with ganciclovir-resistant or refractory CMV infection, 5 (…
CMV infection management in transplant patients in Italy
PA Grossi, F Baldanti, M Andreoni, CF Perno - Journal of Clinical Virology, 2020 - Elsevier
… Time-PCR assays has unravelled the potential of viral load … The resistance may be caused
by genetic mutations of the virus, or … the viral kinetic is similar in both compartments, CMV is …
by genetic mutations of the virus, or … the viral kinetic is similar in both compartments, CMV is …
Cytomegalovirus in hematopoietic stem cell transplant recipients: prevention, diagnosis, and treatment
JF Camargo - Emerging transplant infections: clinical challenges and …, 2021 - Springer
… 40% of patients achieving a plasma viral load of more than … , except that known genetic
mutations conferring resistance are … patients with recurrent or ganciclovir-resistant CMV infection, …
mutations conferring resistance are … patients with recurrent or ganciclovir-resistant CMV infection, …
Human6A, 6B, and Herpesviruses7
H Agut, P Bonnafous… - … Microbiology of the …, 2020 - books.google.com
… and decrease of viral load, as in the case of anti-CMV treatments (110… in case of longitudinal
follow-up. Note that, in ciHHV-6 … Human herpesvirus 6 ganciclovir-resistant strain with amino …
follow-up. Note that, in ciHHV-6 … Human herpesvirus 6 ganciclovir-resistant strain with amino …
[HTML][HTML] The CD4+ T cell response to human cytomegalovirus in healthy and immunocompromised people
… the adaptive immune response to viruses and other pathogens. … CMV retinitis with 14 patients
who did not showed that the … CMV antigens, had lower peak CMV viral loads compared to …
who did not showed that the … CMV antigens, had lower peak CMV viral loads compared to …
[PDF][PDF] Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents
S Chaturvedi, M Pablo, M Wolf, D Rosas-Rivera… - Cell, 2022 - cell.com
… molecular moieties in which a small number of mutations can … molecules could be beneficial
in the context of mutational escape as compared with existing antiviral strategies. In viruses…
in the context of mutational escape as compared with existing antiviral strategies. In viruses…